It has been several years after the events of Shunmuki and Watanuki has become the new proprietor of Yūko's shop following her death. Domeki has taken a position at a university to study folklore and Kohane has become a student at the same university studying under Domeki. Due to Domeki's position, a series of events have occurred that requires Watanuki's services. The episode outlines the process by which Watanuki fulfills the request while presenting changes in many of the characters in the series. The ending theme is "Kaza Nagi" (風なぎ?) by Shikao Suga.

Kimihiro Watanuki is a high school student plagued by ayakashi spirits, both of which are invisible to everyone else but him. The series begins when Watanuki stumbles, seemingly by chance, into a shop that grants wishes. The shop is owned by Yūko Ichihara, a mysterious witch of many names and esoteric renown. For a price, she offers to grant Watanuki's wish to be rid of the spirits. The price, according to Yūko, must be of equal value; so, as payment, he must become Yūko's temporary, part-time cook and housekeeper.

To be free of his dark visions, Kimihiro Watanuki will work for Dimensional Witch Yūko, a mystical woman quick to help those in a bind—for a fee.

新一季的《xxxHOLiC》将继续讲述可以看到鬼四月一日君寻的故事，而在去同学百目鬼的家中帮忙打扫的时候因为破坏了蜘蛛网而右眼突然看不见了…… 　　不得不说CLAMP的作品中眼睛永远不够用，无论是《东京巴比伦》最后两个人还是凑不出三只眼睛这种窘境还是《Tsubasa翼年代记》里还是大家弄到最后都要瞎眼的发展趋势。比较值得注意的是看过漫画版的都可以意识到之后《xxxHOLiC》和《Tsubasa翼年代记》的故事大量互相穿插，不知道此次第二季的故事将怎样呈现这个其实已经快拖入坑的平行交叉世界观了。

故事讲述孤独的高中生四月一日是个能看得见妖怪、吸引妖怪血统的青年。梦想希望抹去自己能力，过着正常人生活的他，某日被一只蝴蝶吸引，踏入了不思议的…

Young substitute teacher Rómeó Baradlay suddenly inherits homeroom duties for class 4C and struggles to keep order, only to develop feelings for one of his students.

Rå is the story of an initiation. Sixteen-year-old Linn longs to be admitted to her father’s community of hunters. She has long been familiar with the rules of the hunt but has yet to prove herself.

In a surreal meeting filled with countless individuals from a variety of backgrounds, nine people recount how sex and sexuality have been used to exert control over their lives. Regardless of race, sexual orientation, nationality, social class, religion, or gender, all are equally shattered and all are equally victims. Those that recount their experiences show that the power / sex dynamic can come in many forms. Whether the power is taken away by physical or psychological means, and regardless of whether it is perpetrated by an individual, institution, or society, the results are equally devastating.

In a surreal meeting filled with countless individuals from a variety of backgrounds, nine people recount how sex and sexuality have been used to exert control over their lives. Regardless of race, sexual orientation, nationality, social class, religion, or gender, all are equally shattered and all are equally victims. Those that recount their experiences show that the power / sex dynamic can come in many forms. Whether the power is taken away by physical or psychological means, and regardless of whether it is perpetrated by an individual, institution, or society, the results are equally devastating.

Invited to a wealthy client's mansion, time-traveling witch Yuko and her companions arrive to find a group of collectors assembled to participate in a mysterious auction. And the mystery only deepens when the collectors go missing one by one. As more guests disappear and strange occurrences abound, Yuko and her friends realize they must solve the mystery before they vanish as well.